Pharmacological Preconditioning With Tumor Necrosis Factor- Activates Signal Transducer and Activator of Transcription-3 at Reperfusion Without Involving Classic Prosurvival Kinases (Akt and Extracellular Signal–Regulated Kinase)
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چکیده
Sandrine Lecour, Naushaad Suleman, Graeme A. Deuchar, Sarin Somers, Lydia Lacerda, Regulated Kinase) − Prosurvival Kinases (Akt and Extracellular Signal Transducer and Activator of Transcription-3 at Reperfusion Without Involving Classic Activates Signal α Pharmacological Preconditioning With Tumor Necrosis FactorPrint ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.105.581058 2005;112:3911-3918; originally published online December 12, 2005; Circulation. http://circ.ahajournals.org/content/112/25/3911 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.
AIMS Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion injury. We propose that IPostC confers its infarct-sparing effect via activation of the newly described prosurvival Survivor Activating Factor Enhancement (SAFE) pathway, which involves the activation of the cytokine tumour necrosis factor al...
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RATIONALE Reduction of myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of ischemia/reperfusion in an organ remote from the heart before sustained myocardial ischemia/reperfusion, was confirmed in all species so far, including humans. OBJECTIVE To identify myocardial signal transduction of cardioprotection by RIPC. METHODS AND RESULTS Anesthetized pigs were...
متن کاملIschemic preconditioning protects by activating prosurvival kinases at reperfusion.
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects the heart against ischemia-reperfusion injury. We hypothesized that ischemic preconditioning (IPC) protects the heart by phosphorylating the prosurvival kinases Akt and ERK-1/2 at reperfusion. In isolated perfused Sprague-Dawley rat hearts subjected to 35 min of leth...
متن کاملDual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning.
AIMS During preconditioning by tumour necrosis factor-alpha (TNFalpha), activation of the signal transducer and activator of transcription-3 (STAT-3) but not Akt, is essential, whereas ischaemic cardiac preconditioning (IPC) requires both STAT-3 and Akt at the time of reperfusion. However, it is not known whether the same signalling pattern occurs during the preconditioning stimulus (trigger ph...
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